CAS 1570231-89-8: APG-1387
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APG-1387, CAS 1570231-89-8:

APG-1387, CAS 1570231-89-8, Stock 67g, Assay 98.26%, White powder, Water 0.19%, Single Impurity 0.23%.

APG-1387

APG-1387, also known as SM-1387, is a IAP inhibitor. APG-1387 promotes the rapid degradation of cIAP1/2 and XIAP, and it exerts an antitumor effect on nasopharyngeal carcinoma cancer stem cells. Further studies show that APG-1387 enhances the chemosensitivity and promotes apoptosis in combination with CDDP and 5-FU of NPC in vitro and vivo.

Product Details:

Name: APG-1387

CAS#: 1570231-89-8

Chemical Formula: C60H72N10O10S2

Exact Mass: 1156.4874

Molecular Weight: 1157.416

Elemental Analysis: C, 62.26; H, 6.27; N, 12.10; O, 13.82; S, 5.54

Specification:

Synonym: APG-1387, APG 1387l; APG1387; SM-1387; SM 1387; SM1387.

IUPAC/Chemical Name: (5S,5'S,8S,8'S,10aR,10a'R)-3,3'-(1,3-phenylenedisulfonyl)bis(N-benzhydryl-5-((S)-2-(methylamino)propanamido)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide)

InChi Key: AKLBERUGKZNEJY-RTEPGWBGSA-N

InChi Code: InChI=1S/C60H72N10O10S2/c1-39(61-3)55(71)63-49-37-67(34-32-45-28-30-51(69(45)59(49)75)57(73)65-53(41-18-9-5-10-19-41)42-20-11-6-12-21-42)81(77,78)47-26-17-27-48(36-47)82(79,80)68-35-33-46-29-31-52(70(46)60(76)50(38-68)64-56(72)40(2)62-4)58(74)66-54(43-22-13-7-14-23-43)44-24-15-8-16-25-44/h5-27,36,39-40,45-46,49-54,61-62H,28-35,37-38H2,1-4H3,(H,63,71)(H,64,72)(H,65,73)(H,66,74)/t39-,40-,45+,46+,49-,50-,51-,52-/m0/s1

SMILES Code: O=C(NC(C1=CC=CC=C1)C2=CC=CC=C2)[C@@H]3CC[C@H](CCN(S(C4=CC=CC(S(N(C[C@@H]5NC([C@H](C)NC)=O)CC[C@@H]6N([C@H](C(NC(C7=CC=CC=C7)C8=CC=CC=C8)=O)CC6)C5=O)(=O)=O)=C4)(=O)=O)C[C@@H]9NC([C@@H](NC)C)=O)N3C9=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: