CAS 1548743-66-3 : BIO-32546

CAS 1548743-66-3 : BIO-32546
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1548743-66-3
  • Stock: 196g
  • Assay: 98.19%

BIO-32546, CAS 1548743-66-3:

BIO-32546CAS 1548743-66-3Stock 196g, Assay 98.19%, White powderWater 0.26%, Single Impurity 0.29%.


BIO-32546, CAS 1548743-66-3

BIO-32546 is an autotaxin (ATX) modulator. BIO-32546 has demonstrated in vivo efficacy in a model of acute pain with good PK/PD correlation. BIO-32546 showed a moderate blocking effect with lowered clearance (CL = 29 mL/min/kg) in rat PK, while maintaining good ATX potency (IC50 = 1.0 ±0.5 nM, N = 5) and low human microsomal clearance (CL =7.6 mL/min/kg). Compound 6 maintained low hERG inhibition (21.3% @ 10 μM) and excellent selectivity over receptors S1P1−5 and LPA1−3,5 (IC50 > 10 μM).


Product Details:

Name: BIO-32546

CAS#: 1548743-66-3

Chemical Formula: C28H31F6NO3

Exact Mass: 543.2208

Molecular Weight: 543.5504

Elemental Analysis: C, 61.87; H, 5.75; F, 20.97; N, 2.58; O, 8.83



Specification:

Synonym: BIO-32546; BIO32546; BIO 32546

IUPAC/Chemical Name: 8-((S)-1-(8-(trifluoromethyl)-7-(((1s,4R)-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)ethyl)-8-azabicyclo[3.2.1]octane-3-carboxylic acid

InChi Key: PZASAAIJIFDWSB-BFWXTJNGSA-N

InChi Code: InChI=1S/C28H31F6NO3/c1-15(35-20-7-8-21(35)13-18(12-20)26(36)37)17-3-2-16-4-11-24(25(23(16)14-17)28(32,33)34)38-22-9-5-19(6-10-22)27(29,30)31/h2-4,11,14-15,18-22H,5-10,12-13H2,1H3,(H,36,37)/t15-,18?,19-,20?,21?,22+/m0/s1

SMILES Code: O=C(C1CC(N2[C@H](C3=CC=C4C=CC(O[C@H]5CC[C@@H](C(F)(F)F)CC5)=C(C(F)(F)F)C4=C3)C)CCC2C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: