CAS 154566-12-8: SB-204990

CAS 154566-12-8: SB-204990
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  • CAS Number: 154566-12-8
  • Stock: 324g
  • Assay: 98.62%

SB-204990, CAS 154566-12-8:

SB-204990, CAS 154566-12-8, Stock 296g, Assay 98.62%, White powder, Water 0.21%, Single Impurity 0.32%.


SB-204990, CAS 154566-12-8

SB-204990 is the prodrug of the potent ATP citrate-lyase inhibitor SB-201076. SB-204990, when administered orally to rats, was absorbed into the systemic circulation; pharmacologically relevant concentrations of SB-201076 were recovered in the liver. SB-204990 (25 mg/kg per day) also decreased plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels. SB-204990 is an important enzyme in controlling substrate supply for lipid synthesis de novo and a potential enzyme target for hypolipidaemic intervention.


Product Details:

Name: SB-204990

CAS#: 154566-12-8

Chemical Formula: C18H22Cl2O5

Exact Mass: 388.0844

Molecular Weight: 389.269

Elemental Analysis: C, 55.54; H, 5.70; Cl, 18.21; O, 20.55



Specification:

Synonym: SB-204990; SB 204990; SB204990

IUPAC/Chemical Name: 2-((3S,5R)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid

InChi Key: YTRNLFYTHYWDAU-KDOFPFPSSA-N

InChi Code: InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1

SMILES Code: O=C(O)C[C@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: