CAS 154447-36-6: LY294002

CAS 154447-36-6: LY294002
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  • CAS Number: 154447-36-6
  • Stock: 466g
  • Assay: 98.62%

LY294002, CAS 154447-36-6

LY294002, CAS 154447-36-6Stock 466g, Assay 98.62%, White powderWater 0.22%, Single Impurity 0.34%.


LY294002

LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.


Product Details:

Name: LY294002

CAS#: 154447-36-6

Chemical Formula: C19H17NO3

Exact Mass: 307.12084

Molecular Weight: 307.34

Elemental Analysis: C, 74.25; H, 5.58; N, 4.56; O, 15.62



Specification:

Synonym: LY294002; LY-294002; LY 294002

IUPAC/Chemical Name: 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

InChi Key: CZQHHVNHHHRRDU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2

SMILES Code: O=C1C=C(N2CCOCC2)OC3=C(C4=CC=CC=C4)C=CC=C13

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not soluble in water.

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: