Umbralisib, CAS 1532533-67-7

  • Umbralisib, CAS 1532533-67-7

Umbralisib, CAS 1532533-67-7
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1532533-67-7
  • Stock: 699g
  • Assay: 98.54%

Umbralisib, CAS 1532533-67-7

Umbralisib, CAS 1532533-67-7Stock 699g, Assay 98.54%, White powderWater 0.44%, Single Impurity 0.32%.


TGR1202 and RP5264

Umbralisib, also known as TGR1202 and RP5264 , is a highly specific, orally available, PI3K delta inhibitor, targeting the delta isoform with nanomolar potency and several fold selectivity over the alpha, beta, and gamma isoforms of PI3K. Inhibition of PI3K delta signaling with TGR-1202 has demonstrated robust activity in numerous pre-clinical models and primary cells from patients with hematologic malignancies.


Product Details:

Name: Umbralisib

CAS#: 1532533-67-7 (free base)

Chemical Formula: C31H24F3N5O3

Exact Mass: 571.18312

Molecular Weight: 571.56

Elemental Analysis: C, 65.14; H, 4.23; F, 9.97; N, 12.25; O, 8.40


Specification:

Related CAS #: 1532533-67-7 (free base)   1532533-75-7 (sulfate)   1532533-78-0 (HCl)    

Synonym: TGR1202; TGR 1202; TGR-1202; RP5264; RP 5264; RP-5264; Umbralisib.

IUPAC/Chemical Name: (S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

InChi Key: IUVCFHHAEHNCFT-INIZCTEOSA-N

InChi Code: InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1

SMILES Code: O=C1C(C2=CC=CC(F)=C2)=C([C@@H](N3C4=NC=NC(N)=C4C(C5=CC=C(C(F)=C5)OC(C)C)=N3)C)OC6=CC=C(F)C=C16

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: