Netarsudil(Mesylate) , CAS 1422144-42-0

  • Netarsudil(Mesylate) , CAS 1422144-42-0

Netarsudil(Mesylate) , CAS 1422144-42-0
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1422144-42-0
  • Stock: 850g
  • Assay: 98.35%

Netarsudil(Mesylate) , CAS 1422144-42-0

Netarsudil(Mesylate) , CAS 1422144-42-0, Stock 850g, Assay 98.35%, White powder, Water 0.26%, Single Impurity 0.46%.


Netarsudil(Mesylate) 

Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and​/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.


Product Details:

Name: Netarsudil Mesylate

CAS#: 1422144-42-0 (mesylate)

Chemical Formula: C30H35N3O9S2

Exact Mass: 645.18147

Molecular Weight: 645.742

Elemental Analysis: C, 55.80; H, 5.46; N, 6.51; O, 22.30; S, 9.93


Specification:

Synonym: AR-13324; AR13324; AR 13324; Netarsudil Mesylate; Rhopressa;

IUPAC/Chemical Name: (S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimethanesulfonate

InChi Key: QQDRLKRHJOAQDC-FBHGDYMESA-N

InChi Code: InChI=1S/C28H27N3O3.2CH4O3S/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;2*1-5(2,3)4/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H3,(H,2,3,4)/t26-;;/m1../s1

SMILES Code: CS(=O)(O)=O.CS(=O)(O)=O.O=C(OCC1=CC=C([C@@H](CN)C(NC2=CC3=C(C=NC=C3)C=C2)=O)C=C1)C4=CC=C(C)C=C4C

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: