LY3039478(Crenigacestat), CAS 1421438-81-4

  • LY3039478(Crenigacestat), CAS 1421438-81-4

LY3039478(Crenigacestat), CAS 1421438-81-4
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1421438-81-4
  • Stock: 1.60kg
  • Assay: 98.73%

LY3039478(Crenigacestat), CAS 1421438-81-4

LY3039478(Crenigacestat), CAS 1421438-81-4, Stock 1603g, Assay 98.73%, White powder, Water 0.28%, Single Impurity 0.89%.


LY3039478(Crenigacestat)

Crenigacestat, also known as LY3039478, is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. LY3039478 potently inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. LY3039478 is being investigated in Phase I.


Product Details:

Name: Crenigacestat

CAS#: 1421438-81-4

Chemical Formula: C22H23F3N4O4

Exact Mass: 464.16714

Molecular Weight: 464.44

Elemental Analysis: C, 56.89; H, 4.99; F, 12.27; N, 12.06; O, 13.78


Specification:

Synonym: LY3039478; LY 3039478; LY-3039478; Crenigacestat

IUPAC/Chemical Name: 4,4,4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide

InChi Key: YCBAQKQAINQRFW-UGSOOPFHSA-N

InChi Code: InChI=1S/C22H23F3N4O4/c1-13(27-17(31)8-9-22(23,24)25)20(32)28-18-15-6-3-2-5-14(15)16-7-4-10-26-19(16)29(11-12-30)21(18)33/h2-7,10,13,18,30H,8-9,11-12H2,1H3,(H,27,31)(H,28,32)/t13-,18-/m0/s1

SMILES Code: O=C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CN=C3N(CCO)C1=O)=O)CCC(F)(F)F

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: