CAS1420477-60-6: Acalabrutinib (Acp-196)

  • CAS1420477-60-6: Acalabrutinib (Acp-196)

CAS1420477-60-6: Acalabrutinib (Acp-196)
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  • CAS Number: 1420477-60-6
  • Stock: 749g
  • Assay: 98.52%

Acalabrutinib (Acp-196), CAS1420477-60-6

Acalabrutinib (Acp-196), CAS1420477-60-6Stock 749g, Assay 98.52%, White powderWater 0.34%, Single Impurity 0.32%.


Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

Product Details:

Name: Acalabrutinib (ACP-196)

CAS#: 1420477-60-6 (free base)

Chemical Formula: C26H23N7O2

Exact Mass: 465.19132

Molecular Weight: 465.52

Elemental Analysis: C, 67.08; H, 4.98; N, 21.06; O, 6.87


Related CAS #: 1420477-60-6 (free base)   2242394-65-4 (maleate)   2058091-93-1 (3 hydrate)   2058091-94-2 (fumarate)   2058091-96-4 (phosphate)   2058091-99-7 (citrate)   2058091-97-5 (tartrate)   2058092-05-8 (sulfate)  

Synonym: ACP-196; ACP196; ACP 196; Acalabrutinib

IUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide


InChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1

SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001