TRV-130.HCl, CAS 1401031-39-7

TRV-130.HCl, CAS 1401031-39-7, Stock 866g, Assay 98.64%, White powder, Water 0.24%, Single Impurity 0.32%.

Oliceridine HCl

Oliceridine, also known as TRV130, is a µ- opioid receptor agonist, that is currently under evaluation in human clinical trials for the treatment of acute severe pain. It is a functionally selective μ-opioid receptor agonist developed by Trevena Inc. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less β-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine. 

Product Details:

Name: Oliceridine HCl

CAS#: 1401031-39-7 (HCl)

Chemical Formula: C22H30N2O2S

Exact Mass: 386.2028

Molecular Weight: 386.5508

Elemental Analysis: C, 68.36; H, 7.82; N, 7.25; O, 8.28; S, 8.30

Specification:

Related CAS #: 1401031-39-7 (HCl)   1401028-24-7 (free base)    

Synonym: TRV130; TRV 130; TRV130; Oliceridine; Oliceridine HCl; Oliceridine hydrochloride

IUPAC/Chemical Name: (R)-N-((3-methoxythiophen-2-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethanamine hydrochloride

InChi Key: YIIWXYLJZRISQP-ZMBIFBSDSA-N

InChi Code: InChI=1S/C22H30N2O2S.ClH/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22;/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3;1H/t21-;/m1./s1

SMILES Code: COC1=C(CNCC[C@@](C2)(C3=NC=CC=C3)CCOC42CCCC4)SC=C1.[H]Cl

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, soluble in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO or aqueous buffer (preferably in acidic pH)

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: