MT-DADMe-ImmA(MTDIA HCl) , CAS 1399840-35-7

  • MT-DADMe-ImmA(MTDIA HCl) , CAS 1399840-35-7

MT-DADMe-ImmA(MTDIA HCl) , CAS 1399840-35-7
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  • CAS Number: 1399840-35-7
  • Stock: 735g
  • Assay: 98.46%

MT-DADMe-ImmA(MTDIA HCl) , CAS 1399840-35-7

MT-DADMe-ImmA(MTDIA HCl) , CAS 1399840-35-7, Stock 735g, Assay 98.46%, White powder, Water 0.85%, Single Impurity 0.34%.


MT-DADMe-ImmA(MTDIA HCl) 

MTDIA, also known as MT-DADMe-ImmA, and Methylthio-DADMe-Immucillin A, is a MTAP inhibitor. Human 5'-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5'-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage. Transition-state (TS) analogues of MTAP are in development as anticancer candidates. TS analogues of MTAP incorporate a cationic nitrogen and a protonated 9-deazaadenine leaving group, which are mimics of the ribocation transition state. MT-ImmA and MT-DADMe-ImmA are two examples of these TS analogues.


Product Details:

Name: MTDIA HCl

CAS#: 1399840-35-7 (HCl)

Chemical Formula: C13H20ClN5OS

Exact Mass:

Molecular Weight: 329.85

Elemental Analysis: C, 47.34; H, 6.11; Cl, 10.75; N, 21.23; O, 4.85; S, 9.72


Specification:

Synonym: MTDIA; MTDIA HCl; Methylthio-DADMe-Immucillin A; MT-DADMe-ImmA; MT-DADMe-ImmA HCl

IUPAC/Chemical Name: (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-3-hydroxy-4-((methylthio)methyl)pyrrolidin-1-ium chloride

InChi Key: XQKMBJFGNRIATG-UXQCFNEQSA-N

InChi Code: InChI=1S/C13H19N5OS.ClH/c1-20-6-9-4-18(5-10(9)19)3-8-2-15-12-11(8)16-7-17-13(12)14;/h2,7,9-10,15,19H,3-6H2,1H3,(H2,14,16,17);1H/t9-,10+;/m1./s1

SMILES Code: NC(N=CN=C12)=C2NC=C1C[N+]3([H])C[C@@H]([C@H](C3)O)CSC.[Cl-]

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: