Elenbecestat(E2609), CAS 1388651-30-6

Elenbecestat(E2609), CAS 1388651-30-6, Stock 910g, Assay 98.62%, White powder, Water 0.22%, Single Impurity 0.31%.

E2609

Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.

Product Details:

Name: Elenbecestat HCl

CAS#: Elenbecestat HCl

Chemical Formula: C19H20Cl2F3N5O2S

Exact Mass: 437.1133

Molecular Weight: 510.36

Elemental Analysis: C, 44.72; H, 3.95; Cl, 13.89; F, 11.17; N, 13.72; O, 6.27; S, 6.28

Specification:

Related CAS #: 1388149-39-0 (free base)   Elenbecestat HCl    

Synonym: Elenbecestat HCl; Elenbecestat hydrochloride, E2609; E-2609; E 2609, Elenbecestat.

IUPAC/Chemical Name: N-[3-[(4aS,5R,7aS)-2-Amino-5-methyl-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide dihydrochloride

InChi Key: ATUMQXRZYKAHQJ-UTMNPRCUSA-N

InChi Code: InChI=1S/C19H18F3N5O2S.2ClH/c1-9-12-7-30-18(23)27-19(12,8-29-9)11-4-10(2-3-13(11)20)26-17(28)15-6-24-14(5-25-15)16(21)22;;/h2-6,9,12,16H,7-8H2,1H3,(H2,23,27)(H,26,28);2*1H/t9-,12-,19-;;/m1../s1

SMILES Code: O=C(C1=NC=C(C(F)F)N=C1)NC2=CC=C(F)C([C@@]34N=C(N)SC[C@]3([H])[C@@H](C)OC4)=C2.[H]Cl.[H]Cl

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: