GDC-0810(ARN-810), CAS 1365888-06-7

  • GDC-0810(ARN-810), CAS 1365888-06-7

GDC-0810(ARN-810), CAS 1365888-06-7
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1365888-06-7
  • Stock: 954g
  • Assay: 98.64%

GDC-0810(ARN-810), CAS 1365888-06-7

GDC-0810(ARN-810), CAS 1365888-06-7Stock 954g, Assay 98.64%, White powderWater 0.26%, Single Impurity 0.32%.


Brilanestrant, also known as GDC-0810, ARN-810 and RG6046, an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. GDC-0810 functions by binding to the estrogen receptor, inducing a conformational change resulting in the degradation of the receptor. GDC-0810 or ARN-810 demonstrates robust activity in models of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer.

Product Details:

Name: Brilanestrant

CAS#: 1365888-06-7

Chemical Formula: C26H20ClFN2O2

Exact Mass: 446.11973

Molecular Weight: 446.9064

Elemental Analysis: C, 69.88; H, 4.51; Cl, 7.93; F, 4.25; N, 6.27; O, 7.16


Synonym: GDC0810; GDC 0810; GDC-0810; ARN810; ARN 810; ARN-810; RG6046; RG-6046; RG 6046; Brilanestrant

IUPAC/Chemical Name: (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid


InChi Code: InChI=1S/C26H20ClFN2O2/c1-2-21(22-10-9-20(28)14-23(22)27)26(18-8-11-24-19(13-18)15-29-30-24)17-6-3-16(4-7-17)5-12-25(31)32/h3-15H,2H2,1H3,(H,29,30)(H,31,32)/b12-5+,26-21+

SMILES Code: O=C(O)/C=C/C1=CC=C(C=C1)/C(C2=CC3=C(NN=C3)C=C2)=C(CC)\C4=CC=C(C=C4Cl)F

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001