ONO-4059(Tirabrutinib), CAS 1351636-18-4

  • ONO-4059(Tirabrutinib), CAS  1351636-18-4

ONO-4059(Tirabrutinib), CAS 1351636-18-4
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1351636-18-4
  • Stock: 629g
  • Assay: 98.85%

ONO-4059(Tirabrutinib), CAS  1351636-18-4

ONO-4059(Tirabrutinib), CAS  1351636-18-4Stock 629g, Assay 98.85%, White powderWater 0.64%, Single Impurity 0.71%.


Tirabrutinib, also known as ONO-4059 and GS-4059, is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. As a result, this agent may inhibit the proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

Product Details:

Name: Tirabrutinib free base

CAS#: 1351636-18-4 (free base)

Chemical Formula: C25H22N6O3

Exact Mass: 454.1753

Molecular Weight: 454.49

Elemental Analysis: C, 66.07; H, 4.88; N, 18.49; O, 10.56


Synonym: ONO-4059; ONO4059; ONO 4059; ONO-4059; GS 4059; GS-4059; GS4059; ONO-WG-307; Tirabrutinib

IUPAC/Chemical Name: (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one


InChi Code: InChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1


Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001