GSK-2656157, CAS 1337532-29-2

  • GSK-2656157, CAS 1337532-29-2

GSK-2656157, CAS 1337532-29-2
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1337532-29-2
  • Stock: 789g
  • Assay: 98.56%

GSK-2656157, CAS 1337532-29-2

GSK-2656157, CAS 1337532-29-2Stock 789g, Assay 98.56%, White powderWater 0.24%, Single Impurity 0.32%.


GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC50 of 0.9 nM. It is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases. GSK2656157 inhibits PERK activity in cells with an IC50 in the range of 10-30 nM as shown by inhibition of stress-induced PERK autophosphorylation, eIF2α substrate phosphorylation, together with corresponding decreases in ATF4 and CHOP proteins in multiple cell lines. Oral administration of GSK2656157 to mice shows a dose- and time-dependent pharmacodynamic response in pancreas as measured by PERK auto-phosphorylation.

Product Details:

Name: GSK2656157

CAS#: 1337532-29-2

Chemical Formula: C23H21FN6O

Exact Mass: 416.17609

Molecular Weight: 416.45

Elemental Analysis: C, 66.33; H, 5.08; F, 4.56; N, 20.18; O, 3.84


Synonym: GSK2656157; GSK 2656157; GSK-2656157.

IUPAC/Chemical Name: 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone


InChi Code: InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)


Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001