CAS 1290543-63-3: Nirogacestat

  • CAS 1290543-63-3: Nirogacestat

CAS 1290543-63-3: Nirogacestat
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1290543-63-3
  • Stock: 250g
  • Assay: 99.50%

Nirogacestat, CAS 1290543-63-3

Nirogacestat, CAS 1290543-63-3Stock 250g, Assay 99.5%, White powder, Water 0.54%, Single Impurity 0.5%.


Nirogacestat, also known as PF-03084014, is a potent and selective gamma secretase (GS) inhibitor with potential antitumor activity. PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors. Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer. Nirogacestat enhances docetaxel-mediated tumor response and provides a rationale to explore GSIs as adjunct therapy in conjunction with docetaxel for men with CRPC (castration-resistant prostate cancer).

Product Details:

Name: Nirogacestat free base

CAS#: 1290543-63-3 (free base)

Chemical Formula: C27H41F2N5O

Exact Mass: 489.32792

Molecular Weight: 489.65581

Elemental Analysis: C, 66.23; H, 8.44; F, 7.76; N, 14.30; O, 3.27


Synonym: PF-03084014; PF03084014; PF 03084014; PF-3084014; PF3084014; PF 3084014; Nirogacestat

IUPAC/Chemical Name: (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide


InChi Code: InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001