MK-8931(Verubecestat), CAS 1286770-55-5

  • MK-8931(Verubecestat), CAS 1286770-55-5

MK-8931(Verubecestat), CAS 1286770-55-5
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1286770-55-5
  • Stock: 1.04kg
  • Assay: 98.86%

MK-8931(Verubecestat), CAS 1286770-55-5

MK-8931(Verubecestat), CAS 1286770-55-5, Stock 1043g, Assay 98.86%, White powder, Water 0.48%, Single Impurity 0.47%.


MK-8931(Verubecestat)

Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.


Product Details:

Name: Verubecestat free base

CAS#: 1286770-55-5 (free base)

Chemical Formula: C17H17F2N5O3S

Exact Mass: 409.102

Molecular Weight: 409.41

Elemental Analysis: C, 49.87; H, 4.19; F, 9.28; N, 17.11; O, 11.72; S, 7.83


Specification:

Synonym: MK-8931; MK 8931; MK8931; MK-8931-009; SCH 900931; SCH-900931; SCH900931; Verubecestat free base,

IUPAC/Chemical Name: (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide

InChi Key: YHYKUSGACIYRML-KRWDZBQOSA-N

InChi Code: InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1

SMILES Code: O=C(NC1=CC=C(F)C([C@@](C2)(C)N=C(N)N(C)S2(=O)=O)=C1)C3=NC=C(F)C=C3

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: