Encorafenib(LGX-818), CAS 1269440-17-6

  • Encorafenib(LGX-818), CAS 1269440-17-6

Encorafenib(LGX-818), CAS 1269440-17-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1269440-17-6
  • Stock: 996g
  • Assay: 98.66%

Encorafenib(LGX-818), CAS 1269440-17-6

Encorafenib(LGX-818), CAS 1269440-17-6Stock 996g, Assay 98.66%, White powderWater 0.35%, Single Impurity 0.42%.


Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells.

Product Details:

Name: Encorafenib

CAS#: 1269440-17-6

Chemical Formula: C22H27ClFN7O4S

Exact Mass: 539.15178

Molecular Weight: 540.01

Elemental Analysis: C, 48.93; H, 5.04; Cl, 6.57; F, 3.52; N, 18.16; O, 11.85; S, 5.94


Related CAS #: 1269440-17-6   1269440-29-0 (R-isomer of LGX-818)    

Synonym: LGX818; LGX-818; LGX 818; Encorafenib.

IUPAC/Chemical Name: (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate.


InChi Code: InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1

SMILES Code: O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001