Olumacostat Glasaretil, CAS 1261491-89-7
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- CAS Number: 1261491-89-7
- Stock: 1.25kg
- Assay: 98.63%
Olumacostat Glasaretil, CAS 1261491-89-7
Olumacostat Glasaretil, CAS 1261491-89-7, Stock 1248g, Assay 98.63%, White powder, Water 0.85%, Single Impurity 0.57%.
Olumacostat Glasaretil
Olumacostat glasaretil or OG is an acetyl-CoA carboxylase inhibitor. OG inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and was designed to enhance delivery in vivo. Topical application of OG but not TOFA significantly reduced hamster ear sebaceous gland size indicating that this pro-drug approach was critical to obtain the desired activity in vivo.
Product Details:
Name: Olumacostat glasaretil
CAS#: 1261491-89-7
Chemical Formula: C26H43NO7
Exact Mass: 481.304
Molecular Weight: 481.63
Elemental Analysis: C, 64.84; H, 9.00; N, 2.91; O, 23.25
Specification:
Synonym: Olumacostat glasaretil; DRM01B; DRM-01B; DRM 01B.
IUPAC/Chemical Name: 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-(tetradecyloxy)furan-2-carboxylate
InChi Key: FYJLDICZGDFWKP-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H43NO7/c1-4-6-7-8-9-10-11-12-13-14-15-16-19-32-25-18-17-22(34-25)26(30)33-21-23(28)27(3)20-24(29)31-5-2/h17-18H,4-16,19-21H2,1-3H3
SMILES Code: O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O
Appearance: White powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Certifications:
