CH 5424802,Alectinib(HCl), CAS 1256589-74-8

  • CH 5424802,Alectinib(HCl), CAS 1256589-74-8

CH 5424802,Alectinib(HCl), CAS 1256589-74-8
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1256589-74-8
  • Stock: 1.73kg
  • Assay: 98.82%

CH 5424802,Alectinib(HCl), CAS 1256589-74-8

CH 5424802,Alectinib(HCl), CAS 1256589-74-8Stock 1730g, Assay 98.82%, White powderWater 0.37%, Single Impurity 0.59%.


CH 5424802,Alectinib(HCl),

 Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. Alectinib inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. Alectinib (as HCl salt) was approved in Dec. 2015.


Product Details:

Name: Alectinib HCl

CAS#: 1256589-74-8 (HCl)

Chemical Formula: C30H35ClN4O2

Exact Mass:

Molecular Weight: 519.086

Elemental Analysis: C, 69.42; H, 6.80; Cl, 6.83; N, 10.79; O, 6.16


Specification:

Synonym: AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, Alectinib; brand name: Alecensa

IUPAC/Chemical Name: Alectinib hydrochloride

InChi Key: GYABBVHSRIHYJR-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H34N4O2.ClH/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29;/h5-6,15-17,21,32H,4,7-14H2,1-3H3;1H

SMILES Code: N#CC1=CC2=C(C=C1)C3=C(C(C)(C)C4=CC(N5CCC(N6CCOCC6)CC5)=C(CC)C=C4C3=O)N2.[H]Cl

Appearance: White  powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: