Arq-087, CAS 1234356-69-4

  • Arq-087, CAS 1234356-69-4

Arq-087, CAS 1234356-69-4
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  • CAS Number: 1234356-69-4
  • Stock: 1.43kg
  • Assay: 98.67%

Arq-087, CAS 1234356-69-4

Arq-087, CAS 1234356-69-4Stock 1425g, Assay 98.67%, White powderWater 0.39%, Single Impurity 0.28%.


Arq-087

Derazantinib, also known as ARQ-087, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.


Product Details:

Name: Derazantinib

CAS#: 1234356-69-4

Chemical Formula: C29H29FN4O

Exact Mass: 468.2325

Molecular Weight: 468.5764

Elemental Analysis: C, 74.34; H, 6.24; F, 4.05; N, 11.96; O, 3.41


Specification:

Synonym: ARQ 087; ARQ087; ARQ-087; Derazantinib

IUPAC/Chemical Name: (6R)-6-(2-fluorophenyl)-N-(3-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

InChi Key: KPJDVVCDVBFRMU-AREMUKBSSA-N

InChi Code: InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1

SMILES Code: COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: