Larotrectinib (Loxo-101), CAS 1223403-58-4

  • Larotrectinib (Loxo-101), CAS 1223403-58-4

Larotrectinib (Loxo-101), CAS 1223403-58-4
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1223403-58-4
  • Stock: 793g
  • Assay: 98.46%

Larotrectinib (Loxo-101), CAS 1223403-58-4

Larotrectinib (Loxo-101), CAS 1223403-58-4Stock 793g, Assay 98.46%, White powderWater 0.54%, Single Impurity 0.32%.


ARRY-470 and LOXO-101

Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons.


Product Details:

Name: Larotrectinib free base

CAS#: 1223403-58-4 (free base)

Chemical Formula: C21H22F2N6O2

Exact Mass: 428.17723

Molecular Weight: 428.44

Elemental Analysis: C, 58.87; H, 5.18; F, 8.87; N, 19.62; O, 7.47



Specification:

Related CAS #: 1223403-58-4 (free base)   1223405-08-0 (sulfate)  

Synonym: LOXO 101; LOXO-101; LOXO101; ARRY-470; ARRY470; ARRY 470; Larotrectinib; Vitrakvi.

IUPAC/Chemical Name: (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

InChi Key: NYNZQNWKBKUAII-KBXCAEBGSA-N

InChi Code: InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1

SMILES Code: O=C(N1CC[C@@H](C1)O)NC2=C3N=C(N4CCC[C@@H]4C5=CC(F)=CC=C5F)C=CN3N=C2

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: