Etrasimod, CAS 1206123-37-6

  • Etrasimod, CAS 1206123-37-6

Etrasimod, CAS 1206123-37-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1206123-37-6
  • Stock: 891g
  • Assay: 98.64%

Etrasimod, CAS 1206123-37-6

Etrasimod, CAS 1206123-37-6Stock 891g, Assay 98.64%, White powderWater 0.24%, Single Impurity 0.32%.


APD334

Etrasimod, also known as APD334, is a potent, centrally available, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases. APD334 has a favorable PK/PD profile, producing robust lymphocyte lowering at relatively low plasma concentrations in several preclinical species. APD334 was efficacious in a mouse experimental autoimmune encephalomyelitis (EAE) model of MS and a rat collagen induced arthritis (CIA) model and was found to have appreciable central exposure.


Product Details:

Name: Etrasimod

CAS#: 1206123-37-6 (free base)

Chemical Formula: C26H26F3NO3

Exact Mass: 457.18648

Molecular Weight: 457.49321

Elemental Analysis: C, 68.26; H, 5.73; F, 12.46; N, 3.06; O, 10.49


Specification:

Related CAS #: 1206123-37-6 (free base)   1206123-97-8 (arginine)    

Synonym: APD334; APD-334; APD 334; Etrasimod.

IUPAC/Chemical Name: (R)-2-(7-((4-cyclopentyl-3-(trifluoromethyl)benzyl)oxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

InChi Key: MVGWUTBTXDYMND-QGZVFWFLSA-N

InChi Code: InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1

SMILES Code: O=C(O)C[C@H]1CCC2=C1NC3=C2C=C(OCC4=CC=C(C5CCCC5)C(C(F)(F)F)=C4)C=C3

Appearance: Whtie powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: