AZD-1208, CAS 1204144-28-4

  • AZD-1208, CAS 1204144-28-4

AZD-1208, CAS 1204144-28-4
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1204144-28-4
  • Stock: 1.44kg
  • Assay: 98.73%

AZD-1208, CAS 1204144-28-4

AZD-1208, CAS 1204144-28-4, Stock 1435g, Assay 98.73%, White powderWater 0.58%, Single Impurity 0.64%.


AZD-1208

AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies.



Product Details:

Name: AZD-1208

CAS#: 1204144-28-4

Chemical Formula: C21H21N3O2S

Exact Mass: 379.13545

Molecular Weight: 379.48

Elemental Analysis: C, 66.47; H, 5.58; N, 11.07; O, 8.43; S, 8.45


Specification:

Synonym: AZD1208 ; AZD-1208; AZD 1208.

IUPAC/Chemical Name: 5-[[2-[(3R)-3-Aminopiperidin-1-yl]biphenyl-3-yl]methylidene]-1,3-thiazolidine-2,4-dione

InChi Key: MCUJKPPARUPFJM-UWCCDQBKSA-N

InChi Code: InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1

SMILES Code: O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: