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CAS 1184946-99-3 (Chemical Compound Information and Properties)

CAS 1184946-99-3 is a chemical compound that is also known as (S)-1-(2-(2,4-difluorophenyl)-2-hydroxyethoxy)-3-(6-methylpyridin-3-yl)urea. It is a white to off-white powder that is soluble in DMSO and ethanol.

Chemical Properties

The molecular formula of CAS 1184946-99-3 is C16H18F2N4O3, and its molecular weight is 356.33 g/mol. It has a melting point of 196-198°C and a boiling point of 600.5°C at 760 mmHg. The compound has a density of 1.43 g/cm3 and a refractive index of 1.63.

CAS 1184946-99-3 is a potent and selective inhibitor of the protein kinase B-Raf. It has been studied for its potential use in the treatment of cancer, specifically melanoma, which is a type of skin cancer. B-Raf is a protein that is involved in cell signaling pathways that regulate cell growth and division. Mutations in the B-Raf gene are found in approximately 50% of all melanomas, making it an attractive target for drug development.

Safety

There is limited information available on the safety of CAS 1184946-99-3, as it is still in the early stages of development. However, studies have shown that it can cause mild to moderate side effects, including fatigue, nausea, and skin rash. As with any chemical compound, it should be handled with care and in accordance with proper safety protocols.

Conclusion

CAS 1184946-99-3 is a chemical compound that shows promise as a potential treatment for melanoma. Its ability to selectively inhibit B-Raf makes it an attractive target for drug development. Further research is needed to determine its safety and efficacy in humans.