AZD-6482(S), CAS 1173900-37-2

  • AZD-6482(S), CAS 1173900-37-2

AZD-6482(S), CAS 1173900-37-2
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  • CAS Number: 1173900-37-2
  • Stock: 1.33kg
  • Assay: 98.26%

AZD-6482(S), CAS 1173900-37-2

AZD-6482(S), CAS 1173900-37-2, Stock 1327g, Assay 98.26%, White powderWater 0.53%, Single Impurity 0.71%.


AZD-6482(S)

AZD6482 (S-isomer), CAS#1173900-37-2, is an isomer of AZD6482 (MedKoo Cat#406268) with S-configuration. AZD6482 is a potent, selective and ATP competitive PI3Kβ inhibitor (IC(50) 0.01 μm). AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). This is the first human target validation for PI3Kβ inhibition as anti-platelet therapy showing a mild and generalized antiplatelet effect attenuating but not completely inhibiting multiple signaling pathways with an impressive separation towards primary hemostasis. AZD6482 at 'supratherapeutic' plasma concentrations may attenuate insulin signaling, most likely through PI3Kα inhibition.


Product Details:

Name: AZD6482 (S-isomer)

CAS#: 1173900-37-2 (S-isomer)

Chemical Formula: C22H24N4O4

Exact Mass: 408.1798

Molecular Weight: 408.458

Elemental Analysis: C, 64.69; H, 5.92; N, 13.72; O, 15.67


Specification:

Synonym: AZD6482 (S-isomer); AZD6482 (S); AZD6482; AZD-6482; AZD 6482.

IUPAC/Chemical Name: (S)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid

InChi Key: IRTDIKMSKMREGO-HNNXBMFYSA-N

InChi Code: InChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m0/s1

SMILES Code: O=C(O)C1=CC=CC=C1N[C@H](C2=CC(C)=CN(C2=NC(N3CCOCC3)=C4)C4=O)C

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: