Capivasertib (AZD5363), CAS 1143532-39-1

  • Capivasertib (AZD5363), CAS 1143532-39-1

Capivasertib (AZD5363), CAS 1143532-39-1
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1143532-39-1
  • Stock: 799g
  • Assay: 98.62%

Capivasertib (AZD5363), CAS 1143532-39-1

Capivasertib (AZD5363), CAS 1143532-39-1Stock 799g, Assay 98.62%, White powderWater 0.24%, Single Impurity 0.32%.


Capivasertib

AZD5363, also known as Capivasertib, is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components.


Product Details:

Name: Capivasertib

CAS#: 1143532-39-1

Chemical Formula: C21H25ClN6O2

Exact Mass: 428.17275

Molecular Weight: 428.9152

Elemental Analysis: C, 58.81; H, 5.87; Cl, 8.27; N, 19.59; O, 7.46



Specification:

Synonym: AZD5363; AZD-5363; AZD 5363; Capivasertib

IUPAC/Chemical Name: (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

InChi Key: JDUBGYFRJFOXQC-KRWDZBQOSA-N

InChi Code: InChI=1S/C21H25ClN6O2/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26)/t17-/m0/s1

SMILES Code: O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: