Dacomitinib, CAS 1110813-31-4

  • Dacomitinib, CAS 1110813-31-4

Dacomitinib, CAS 1110813-31-4
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1110813-31-4
  • Stock: 993g
  • Assay: 98.64%

Dacomitinib, CAS 1110813-31-4

Dacomitinib, CAS 1110813-31-4Stock 993g, Assay 98.64%, White powderWater 0.24%, Single Impurity 0.32%.


PF-299

Dacomitinib, also known as PF-299 and PF-00299804 ; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.


Product Details:

Name: Dacomitinib

CAS#: 1110813-31-4 (free)

Chemical Formula: C24H25ClFN5O2

Exact Mass: 469.16808

Molecular Weight: 469.94

Elemental Analysis: C, 61.34; H, 5.36; Cl, 7.54; F, 4.04; N, 14.90; O, 6.81



Specification:

Related CAS #: 1110813-31-4 (free)   1042385-75-0 (hydrate)   1262034-38-7    

Synonym: PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804; PF-299; PF299; PF 299; Dacomitinib; Vizimpro;

IUPAC/Chemical Name: (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide

InChi Key: LVXJQMNHJWSHET-AATRIKPKSA-N

InChi Code: InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+

SMILES Code: O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=C/CN4CCCCC4

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: