BMS-777607, CAS 1025720-94-8

  • BMS-777607, CAS 1025720-94-8

BMS-777607, CAS 1025720-94-8
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1025720-94-8
  • Stock: 1.59kg
  • Assay: 98.82%

BMS-777607, CAS 1025720-94-8

BMS-777607, CAS 1025720-94-8, Stock 1590g, Assay 98.82%, White powderWater 0.25%, Single Impurity 0.49%.


BMS-777607

BMS-777607, also known as BMS-817378 and ASLAN-002, a Met tyrosine kinase inhibitor, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.


Product Details:

Name: BMS-777607

CAS#: 1025720-94-8

Chemical Formula: C25H19ClF2N4O4

Exact Mass: 512.10629

Molecular Weight: 512.89

Elemental Analysis: C, 58.54; H, 3.73; Cl, 6.91; F, 7.41; N, 10.92; O, 12.48


Specification:

Synonym: BMS817378; BMS 817378; BMS-817378; BMS 777607; BMS-777607; BMS777607; ASLAN 002; ASLAN-002; ASLAN002.

IUPAC/Chemical Name: N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide.

InChi Key: VNBRGSXVFBYQNN-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)

SMILES Code: O=C(C1=C(OCC)C=CN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C(Cl)C(N)=NC=C4)C(F)=C3

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years)

Solubility: Soluble in DMSO at 40mg / mL, not soluble in water, not soluble in ethanol.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: