CAS 1025065-69-3: SGI-1776
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SGI-1776, CAS 1025065-69-3

SGI-1776,  CAS 1025065-69-3, Stock 170g, Assay 99.7%, White powder, Water 0.34%, Single Impurity 0.3%.

SGI-1776

SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.

Product Details:

Name: SGI-1776

CAS#: 1025065-69-3

Chemical Formula: C20H22F3N5O

Exact Mass: 405.17764

Molecular Weight: 405.42

Elemental Analysis: C, 59.25; H, 5.47; F, 14.06; N, 17.27; O, 3.95

Specification:

Synonym: SGI1776; SGI-1776; SGI 1776.

IUPAC/Chemical Name: N-((1-methylpiperidin-4-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine.

InChi Key: SXLKQFDJPFXMGV-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22F3N5O/c1-27-10-8-14(9-11-27)12-24-18-6-7-19-25-13-17(28(19)26-18)15-2-4-16(5-3-15)29-20(21,22)23/h2-7,13-14H,8-12H2,1H3,(H,24,26)

SMILES Code: FC(F)(F)OC1=CC=C(C2=CN=C3C=CC(NCC4CCN(C)CC4)=NN32)C=C1

Appearance: white solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: