MK5046, CAS 1022152-70-0

MK5046, CAS 1022152-70-0, Stock 470g, Assay 99.7%, White powder, Water 0.35%, Single Impurity 0.3%.

MK5046

MK5046 is a novel bombesin receptor subtype-3 agonist. MK5046 effectively reduced body weight in rats and caused modest increases in body temperature, heart rate, and blood pressure. MK-5046 is the first BRS-3 agonist with properties suitable for use in larger mammals. In dogs, MK-5046 treatment produced statistically significant and persistent weight loss, which was initially accompanied by increases in body temperature and heart rate that abated with continued dosing. MK-5046 may be useful for treatment of obesity.

Product Details:

Name: MK5046

CAS#: 1022152-70-0

Chemical Formula: C20H18F6N4O

Exact Mass: 444.13848

Molecular Weight: 444.37

Elemental Analysis: C, 54.06; H, 4.08; F, 25.65; N, 12.61; O, 3.60

Specification:

Synonym: MK5046; MK-5046; MK 5046.

IUPAC/Chemical Name: (S)-2-(4-(1H-pyrazol-1-yl)phenyl)-1,1,1-trifluoro-3-(4-((1-(trifluoromethyl)cyclopropyl)methyl)-1H-imidazol-2-yl)propan-2-ol

InChi Key: UJINBEQCDMOAHM-SFHVURJKSA-N

InChi Code: InChI=1S/C20H18F6N4O/c21-19(22,23)17(6-7-17)10-14-12-27-16(29-14)11-18(31,20(24,25)26)13-2-4-15(5-3-13)30-9-1-8-28-30/h1-5,8-9,12,31H,6-7,10-11H2,(H,27,29)/t18-/m0/s1

SMILES Code: O[C@@](CC1=NC(CC2(C(F)(F)F)CC2)=CN1)(C3=CC=C(N4N=CC=C4)C=C3)C(F)(F)F

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: