CAS 1020719-78-1: Sulfadiazine-d4

  • CAS 1020719-78-1: Sulfadiazine-d4

CAS 1020719-78-1: Sulfadiazine-d4
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  • CAS Number: 1020719-78-1
  • Stock: 500g
  • Assay: 99.50%

Sulfadiazine-d4, CAS 1020719-78-1

Sulfadiazine-d4, CAS 1020719-78-1, Stock 500g, Assay 99.5%, White powder, Water 0.39%, Single Impurity 0.5%.


Sulfadiazine-d4 is intended for use as an internal standard for the quantification of sulfadiazine by GC- or LC-MS. Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA) to dihydropteroate, an intermediate in folate biosynthesis. Sulfadiazine inhibits recombinant P. carinii DHPS (IC50 = 0.19 μM). It is active against clinical isolates of M. tuberculosis (MIC90 = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L). Sulfadiazine is also active against A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90s = <0.5 mg/ml for all) when used in combination with trimethoprim. In vivo, sulfadiazine (40 mg/kg per day) increases survival in a mouse model of lethal T. gondii infection when administered in combination with pyrimethamine. Formulations containing sulfadiazine have been used in the treatment of rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.

Product Details:

Name: Sulfadiazine-d4

CAS#: 1020719-78-1

Chemical Formula: C10H6D4N4O2S

Exact Mass: 254.0776

Molecular Weight: 254.3004

Elemental Analysis: C, 47.23; H, 5.55; N, 22.03; O, 12.58; S, 12.61


Synonym: Sulfadiazine-d4; Sulfadiazine d4;

IUPAC/Chemical Name: 4-amino-N-(pyrimidin-2-yl)benzene-2,3,5,6-d4-sulfonamide


InChi Code: InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)/i2D,3D,4D,5D

SMILES Code: O=S(NC1=NC=CC=N1)(C2=C(C([2H])=C(N)C([2H])=C2[2H])[2H])=O

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001