Fosdevirine, CAS 1018450-26-4

Fosdevirine, CAS 1018450-26-4, Stock 296g, Assay 99.5%, White powder, Water 0.43%, Single Impurity 0.5%.

Fosdevirine

Fosdevirine, also known as GSK2248761 and IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor having an EC50 of 11 nM against the Y181C/K103N double mutant. GSK2248761 is a novel, once-daily (QD), next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) with activity against efavirenz-resistant strains. GSK2248761 at 100 to 800 mg QD for 7 days was well tolerated, demonstrated potent antiviral activity in treatment-naive HIV-infected subjects, and had favorable PK and resistance profiles. GSK2248761 is no longer in clinical development.

Product Details:

Name: Fosdevirine

CAS#: 1018450-26-4

Chemical Formula: C20H17ClN3O3P

Exact Mass: 413.0696

Molecular Weight: 413.7978

Elemental Analysis: C, 58.05; H, 4.14; Cl, 8.57; N, 10.15; O, 11.60; P, 7.49

Specification:

Synonym: GSK2248761; GSK-2248761; GSK 2248761; GSK2248761A; GSK-2248761A; GSK 2248761A; IDX899; IDX-899; IDX 899, Fosdevirine.

IUPAC/Chemical Name: methyl (E)-(2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinate

InChi Key: CGBYTKOSZYQOPV-ONEGZZNKSA-N

InChi Code: InChI=1S/C20H17ClN3O3P/c1-12-8-13(4-3-7-22)10-15(9-12)28(26,27-2)19-16-11-14(21)5-6-17(16)24-18(19)20(23)25/h3-6,8-11,24H,1-2H3,(H2,23,25)/b4-3+

SMILES Code: O=P(C1=CC(C)=CC(/C=C/C#N)=C1)(C2=C(C(N)=O)NC3=C2C=C(Cl)C=C3)OC

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: