Tenovin-6 HCl, CAS 1011301-29-3

Tenovin-6 HCL, CAS 1011301-29-3, Stock 490g, Assay 99.6%, White powder, Water 0.27%, Single Impurity 0.4%.

Tenovin-6 HCl

Tenovin-6, also known as Tnv-6, is a bioactive small molecule SIRT2 inhibitor with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Tnv-6 causes non-genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to Tnv-6 did not induce cellular apoptosis or p53-pathway activity. Transcriptomic profiling identified a gene program influenced by Tnv-6 that included autophagy-lysosomal pathway genes.

Product Details:

Name: Tenovin-6 HCl

CAS#: 1011301-29-3 (HCl)

Chemical Formula: C25H35ClN4O2S

Exact Mass:

Molecular Weight: 491.09

Elemental Analysis: C, 61.14; H, 7.18; Cl, 7.22; N, 11.41; O, 6.52; S, 6.53

Specification:

Synonym: Tenovin6; Tenovin 6; Tenovin-6; Tnv-6; Tenovin-6 HCl

IUPAC/Chemical Name: 4-(tert-butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide hydrochloride

InChi Key: UBNCTIDXQDCEPI-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H34N4O2S.ClH/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5;/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32);1H

SMILES Code: O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2.[H]Cl

Appearance: Yellow solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: