CAS 1000852-17-4: Crolibulin
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- CAS Number: 1000852-17-4
- Stock: 259g
- Assay: 99.70%
Crolibulin, CAS 1000852-17-4
Crolibulin, CAS 1000852-17-4, Stock 259g, Assay 99.7%, White powder, Water 0.19%, Single Impurity 0.3%.
Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.
Chemical Formula: C18H17BrN4O3
Exact Mass: 416.0484
Molecular Weight: 417.26
Elemental Analysis: C, 51.81; H, 4.11; Br, 19.15; N, 13.43; O, 11.50
Synonym: EPC2407; EPC 2407; EPC-2407; Crolibulin crinobulin.
IUPAC/Chemical Name: (R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
InChi Key: JXONINOYTKKXQQ-CQSZACIVSA-N
InChi Code: InChI=1S/C18H17BrN4O3/c1-24-13-6-8(5-11(19)17(13)25-2)14-9-3-4-12(21)15(22)16(9)26-18(23)10(14)7-20/h3-6,14H,21-23H2,1-2H3/t14-/m1/s1
SMILES Code: N#CC1=C(N)OC2=C(C=CC(N)=C2N)[C@H]1C3=CC(OC)=C(OC)C(Br)=C3
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001