A-867744, CAS 1000279-69-5 

A-867744, CAS 1000279-69-5 , Stock 397g, Assay 99.8%, White powder, Water 0.13%, Single Impurity 0.2%.

A-867744

A-867744 is a type II PAM with good potency and selectivity. A-867744 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, A-867744 normalized gating deficits.A-867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. A-867744 potentiated acetylcholine (ACh)-evoked currents, with an EC(50) value of approximately 1 microM

Product Details:

Name: A-867744

CAS#: 1000279-69-5

Chemical Formula: C20H19ClN2O3S

Exact Mass: 402.0805

Molecular Weight: 402.893

Elemental Analysis: C, 59.62; H, 4.75; Cl, 8.80; N, 6.95; O, 11.91; S, 7.96

Specification:

Synonym: A-867744; A 867744; A867744;

IUPAC/Chemical Name: 4-(5-(4-Chlorophenyl)-2-methyl-3-propionylpyrrol-1-yl)benzenesulfonamide

InChi Key: ABACVOXFUHDKNZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19ClN2O3S/c1-3-20(24)18-12-19(14-4-6-15(21)7-5-14)23(13(18)2)16-8-10-17(11-9-16)27(22,25)26/h4-12H,3H2,1-2H3,(H2,22,25,26)

SMILES Code: O=S(C1=CC=C(N2C(C)=C(C(CC)=O)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: