Vadadustat(AKB-6548), CAS 1000025-07-9

  • Vadadustat(AKB-6548), CAS 1000025-07-9

Vadadustat(AKB-6548), CAS 1000025-07-9
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1000025-07-9
  • Stock: 890g
  • Assay: 98.64%

Vadadustat(AKB-6548), CAS 1000025-07-9

Vadadustat(AKB-6548), CAS 1000025-07-9Stock 890g, Assay 98.64%, White powderWater 0.44%, Single Impurity 0.32%.


Vadadustat

Vadadustat, also known as AKB-6548 and PG-1016548, is a potent Hypoxia-inducible factor-proline dioxygenase inhibitor. AKB-6548 works by inhibiting hypoxia inducible factor-prolyl hydroxylase (HIP-PH), leading to stabilization and increased levels of HIFα. In turn HIFα improves production of hemoglobin and red blood cells (RBCs), while maintaining normal levels of erythropoietin (EPO) in patients. We believe this differentiated mechanism of action has the potential to be safer than that of injectable recombinant erythropoietin stimulating agents (rESAs), avoiding supra-physiological levels of EPO and saturation of EPO receptors for prolonged periods of time.


Product Details:

Name: Vadadustat

CAS#: 1000025-07-9

Chemical Formula: C14H11ClN2O4

Exact Mass: 306.0407

Molecular Weight: 306.7

Elemental Analysis: C, 54.83; H, 3.62; Cl, 11.56; N, 9.13; O, 20.87



Specification:

Synonym: AKB-6548; AKB 6548; AKB6548; PG-1016548; PG 1016548; PG1016548; B-506; B506; Vadadustat

IUPAC/Chemical Name: (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycine

InChi Key: JGRXMPYUTJLTKT-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)

SMILES Code: O=C(O)CNC(C1=NC=C(C2=CC=CC(Cl)=C2)C=C1O)=O

Appearance: White powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: