Ripretinib, 1442472-39-0, Stock 249g, World biggest supplier.

Ripretinib, 1442472-39-0, Stock 249g, World biggest supplier.

Ripretinib, 1442472-39-0 (free base), HPLC 99.64%, HNMR, MASS, HPLC, COA, MSDS we supply.

Ripretinib, 1442472-39-0 (free base), batch size 1kg, White powder.

Ripretinib, also known as DCC-2618, is a potent, orally active and selective KIT/PDGFR inhibitor with potential antineoplastic activity. DCC-2618 targets and binds to both wild-type and mutant forms of KIT and PDGFRa specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. In May 2020, FDA Approves Qinlock (ripretinib) for the Treatment of Fourth-Line Gastrointestinal Stromal Tumor

Name: Ripretinib free base

CAS#: 1442472-39-0 (free base)

Chemical Formula: C24H21BrFN5O2

Exact Mass: 509.0863

Molecular Weight: 510.3674

Elemental Analysis: C, 56.48; H, 4.15; Br, 15.66; F, 3.72; N, 13.72; O, 6.27

Synonym: DCC-2618; DCC 2618; DCC2618; DP 2618; DP-2618; DP2618; Ripretinib;

IUPAC/Chemical Name: 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea


InChi Code: InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33)


Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

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