AMG-176, CAS 1883727-34-1
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- CAS Number: 1883727-34-1
- Stock: 90g
- Assay: 98.80%
AMG-176, CAS 1883727-34-1
AMG-176, CAS 1883727-34-1, Stock 90g, Assay 98.8%, White powder, Water 0.05%, Single Impurity 0.04%.
AMG-176
AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
Produt Details:
Name: AMG-176
CAS#: 1883727-34-1
Chemical Formula: C33H41ClN2O5S
Exact Mass: 612.24
Molecular Weight: 613.210
Elemental Analysis: C, 64.64; H, 6.74; Cl, 5.78; N, 4.57; O, 13.05; S, 5.23
Specification:
Synonym: AMG-176; AMG 176; AMG176; tapotoclax; tapotoclaxum.
IUPAC/Chemical Name: Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)- naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl- , 10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-
InChi Key: JQNINBDKGLWYMU-GEAQBIRJSA-N
InChi Code: InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4+/t21-,22+,25-,27+,30-,33-/m0/s1
SMILES Code: O=C(N1)C2=CC(N(C[C@H]3[C@@H](CC3)[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S1(=O)=O)C4)=C(C=C2)OC[C@@]54CCCC6=CC(Cl)=CC=C65
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001