The use of Clovoxamine in the treatment

Oct 28, 2018

Original Route of Synthesis of  Clovoxamine yield is about 11%, impurity is 2%, unknown impurity is 1%.


EOS Med Chem use the new Route of Synthesis of Clovoxamine, yield improve 32%.


Reduced Clovoxamine synthesis steps, Remove unknown impurity, Remove Toxic Chemicals, Impurity is less than 1%, Assay more than 99%, Water by KF less than 0.5%.


Below is EOS Med Chem Route of Synthesis of Clovoxamine, each steps we have MSDS, COA, if you have interesting, pls contact me.

Name: Clovoxamine fumarate
CAS#: 54739-19-4 (free base)
Chemical Formula: C18H25ClN2O6
Exact Mass: 284.1292
Molecular Weight: 400.856
Elemental Analysis: C, 53.93; H, 6.29; Cl, 8.84; N, 6.99; O, 23.95


Related CAS #: 54739-21-8 (fumarate)   54739-19-4 (free base) 

Synonym: Clovoxamine fumarate; DU 23811; DU-23811; DU23811.

IUPAC/Chemical Name: 4'-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime fumarate

InChi Key: HOFGGHPYWKSXTN-QCHLHFLZSA-N

InChi Code: InChI=1S/C14H21ClN2O2.C4H4O4/c1-18-10-3-2-4-14(17-19-11-9-16)12-5-7-13(15)8-6-12;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,16H2,1H3;1-2H,(H,5,6)(H,7,8)/b17-14+;2-1+

SMILES Code: COCCCC/C(C1=CC=C(Cl)C=C1)=N\OCCN.OC(/C=C/C(O)=O)=O


TECHNICAL DATA
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

 

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