Biggest Nazartinib 1508250-71-2 supplier, stock 1.8kg

May 16, 2019

Biggest Nazartinib 1508250-71-2 supplier, stock 1.8kg

 
2019 CHINA CPHI  E2A62
2019 WORLD CPHI 101C45

Web: www.eosmedchem.com
Email: info@eosmedchem.com; eosmedchem@gmail.com

Biggest Nazartinib , 1508250-71-2 supplier, stock 1.8kg
 
 
 

Nazartinib, also known as EGF816 and NVS-816, is an orally available, irreversible, third-generation, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. EGF816 covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M EGFR mutant, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGF816 preferentially inhibits mutated forms of EGFR including T790M, a secondarily acquired resistance mutation, and may have therapeutic benefits in tumors with T790M-mediated resistance when compared to other EGFR tyrosine kinase inhibitors.

Nazartinib Intermediate: Pilot scale Intermeidates: 1032684-85-7, 1508258-34-1.

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Name: Nazartinib
CAS#: 1508250-71-2
Chemical Formula: C26H31ClN6O2
Exact Mass: 494.2197
Molecular Weight: 495.02
Elemental Analysis: C, 63.09; H, 6.31; Cl, 7.16; N, 16.98; O, 6.46


Synonym: EGF816; EGF-816; EGF 816; NVS-816; NVS 816; NVS816; Nazartinib.

IUPAC/Chemical Name: (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide

InChi Key: IOMMMLWIABWRKL-WUTDNEBXSA-N

InChi Code: InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1

SMILES Code: O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)=C4

World biggest manufacturerNazartinib 1508250-71-2, ee99.9%.

Nazartinib 1508250-71-2 stable novel crystalline or amorphous form both we have, Nazartinib 1508250-71-2no any IP problem. Nazartinib 1508250-71-2 DMF filling, free sample of Nazartinib 1508250-71-2.

EOS Med Chem have already carried out Nazartinib 1508250-71-2 batch production, also have completed the development of quality standards and process validation. The stable process is the guarantee of product quality. For Nazartinib 1508250-71-2 , we use HPLC-UV detection instead of other companies' HPLC-ELSD test, Our detection method is more sensitive.

Nazartinib 1508250-71-2 stock more than 500g, HPLC 99%, HNMR, MASS, COA, MSDS we have. Nazartinib 1508250-71-2 chrial purity more than 99%, single impurity less than 0.1%, White powder.

Nazartinib 1508250-71-2, free sample, welcome to ask: info@eosmedchem.com ; eosmedchem@gmail.com

2019 CHINA CPHI  E2A62
2019 WORLD CPHI 101C45
FDA New, GMP Do
Clinical Phase II, III Intermediates
GMP Custom synthesis, Full Document

R&D Center: 8000 sq, More than 100 hoods
Pilot Plant: 20000sq, 40 reactors from 5-200L
Manufacturing Site: 800000sq, 40 reactors from 100-5000L
Web: www.eosmedchem.com
Email: info@eosmedchem.com; eosmedchem@gmail.com
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