Biggest GSK547 |CAS:2226735-55-1 supplier

Mar 26, 2019
Biggest GSK547 |CAS:2226735-55-1 supplier



GSK547 is a highly selective and potent inhibitor of RIP1 kinase that targets RIP1 in vivo.
 
EOS Med Chem poduce GSK547 CAS:2226735-55-1, stock 30g, HPLC 99%, HNMR, MASS, COA is ok.
 
hemical Formula: C20H18F2N6O 
Exact Mass: 396.151 
Molecular Weight: 396.4 
Elemental Analysis: C, 60.60; H, 4.58; F, 9.59; N, 21.20; O, 4.04
 
Synonym: GSK547, GSK-547, GSK 547, RIP1i
IUPAC/Chemical Name: (S)-6-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile
InChi Key: SJVGFKBLUYAEOK-SFHVURJKSA-N
InChi Code: InChI=1S/C20H18F2N6O/c21-15-7-14(8-16(22)9-15)18-1-4-26-28(18)20(29)13-2-5-27(6-3-13)19-10-17(11-23)24-12-25-19/h4,7-10,12-13,18H,1-3,5-6H2/t18-/m0/s1
SMILES Code: N#CC1=NC=NC(N2CCC(C(N3N=CC[C@H]3C4=CC(F)=CC(F)=C4)=O)CC2)=C1
 
 
GSK547 (RIP1i, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo; exhibited a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963; reprogrammed TAMs toward an MHCIIhiTNFα+IFNγ+ immunogenic phenotype in a STAT1-dependent manner. RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human Pancreatic ductal adenocarcinoma (PDA).
 
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