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CAS Number：1000025-07-9
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SMILES：Vadadustat, CAS 1000025-07-9Vadadustat, CAS 1000025-07-9, Stock 480g, Assay 99.5%, White powder, Water 0.54%, Single Impurity 0.5%.VadadustatVadadustat, also known as AKB-6548 and PG-1016548, is a potent Hypoxia-inducible factor-proline dioxygenase inhibitor. AKB-6548 works by inhibiting hypoxia inducible factor-prolyl hydroxylase (HIP-PH), leading to stabilization and increased levels of HIF??. In turn HIF?? improves production of hemoglobin and red blood cells (RBCs), while maintaining normal levels of erythropoietin (EPO) in patients. We believe this differentiated mechanism of action has the potential to be safer than that of injectable recombinant erythropoietin stimulating agents (rESAs), avoiding supra-physiological levels of EPO and saturation of EPO receptors for prolonged periods of time.Product Details:Name: VadadustatCAS#: 1000025-07-9Chemical Formula: C14H11ClN2O4Exact Mass: 306.0407Molecular Weight: 306.7Elemental Analysis: C, 54.83; H, 3.62; Cl, 11.56; N, 9.13; O, 20.87Specification:Synonym:?AKB-6548; AKB 6548; AKB6548; PG-1016548; PG 1016548; PG1016548; B-506; B506;?VadadustatIUPAC/Chemical Name:?(5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycineInChi Key:?JGRXMPYUTJLTKT-UHFFFAOYSA-NInChi Code:?InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)SMILES Code:?O=C(O)CNC(C1=NC=C(C2=CC=CC(Cl)=C2)C=C1O)=OAppearance:?White to off-white solid powder.Purity:?>98% (or refer to the Certificate of Analysis)Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility:?Soluble in DMSO, not in waterShelf Life:?>2 years if stored properlyDrug Formulation:?This drug may be formulated in DMSOHS Tariff Code:?2934.99.9001Certification: