Products

CAS Number：1018450-26-4
Catalog Number:
Chemcial Name:
MW(Molecular Weight)：
MF(Molecular Formula):
SMILES：Fosdevirine, CAS 1018450-26-4Fosdevirine, CAS?1018450-26-4,?Stock 296g,?Assay?99.5%,?White powder, Water?0.43%,?Single Impurity?0.5%.FosdevirineFosdevirine, also known as GSK2248761 and IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor having an EC50 of 11 nM against the Y181C/K103N double mutant. GSK2248761 is a novel, once-daily (QD), next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) with activity against efavirenz-resistant strains. GSK2248761 at 100 to 800 mg QD for 7 days was well tolerated, demonstrated potent antiviral activity in treatment-naive HIV-infected subjects, and had favorable PK and resistance profiles. GSK2248761 is no longer in clinical development.Product Details:Name: FosdevirineCAS#: 1018450-26-4Chemical Formula: C20H17ClN3O3PExact Mass: 413.0696Molecular Weight: 413.7978Elemental Analysis: C, 58.05; H, 4.14; Cl, 8.57; N, 10.15; O, 11.60; P, 7.49Specification:Synonym: GSK2248761; GSK-2248761; GSK 2248761; GSK2248761A; GSK-2248761A; GSK 2248761A; IDX899; IDX-899; IDX 899, Fosdevirine.IUPAC/Chemical Name: methyl (E)-(2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinateInChi Key: CGBYTKOSZYQOPV-ONEGZZNKSA-NInChi Code: InChI=1S/C20H17ClN3O3P/c1-12-8-13(4-3-7-22)10-15(9-12)28(26,27-2)19-16-11-14(21)5-6-17(16)24-18(19)20(23)25/h3-6,8-11,24H,1-2H3,(H2,23,25)/b4-3+SMILES Code: O=P(C1=CC(C)=CC(/C=C/C#N)=C1)(C2=C(C(N)=O)NC3=C2C=C(Cl)C=C3)OCAppearance: Solid powderPurity: >99% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: