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CAS Number：1152311-62-0
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SMILES：VX-661, CAS 1152311-62-0VX-661, CAS 1152311-62-0,?Stock?893g,?Assay?98.84%,?White powder,?Water?0.54%,?Single Impurity?0.38%.VX-661Tezacaftor, also known asVX-661, is CFTR modulator. VX-661 is potentially useful for treatment of cystic fibrosis disease. Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, ??508CFTR, produces a protein that is misfolded and does not reach the cell membrane. VX-661 can correct trafficking of ??508CFTR and partially restore chloride channel activity.Product Details:Name: Tezacaftor (VX-661)CAS#: 1152311-62-0Chemical Formula: C26H27F3N2O6Exact Mass: 520.18212Molecular Weight: 520.5Elemental Analysis: C, 60.00; H, 5.23; F, 10.95; N, 5.38; O, 18.44Specification:Synonym: VX-661; VX661; VX 661; Tezacaftor. Trikafta.IUPAC/Chemical Name: (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamideInChi Key: MJUVRTYWUMPBTR-MRXNPFEDSA-NInChi Code: InChI=1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1SMILES Code: O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=CC5=C(N(C[C@@H](O)CO)C(C(C)(C)CO)=C5)C=C4FAppearance: white powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: