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CAS Number：1253952-02-1
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SMILES：Netarsudil HCl, CAS 1253952-02-1Netarsudil HCl, CAS 1253952-02-1,?Stock?744g,?Assay?98.35%,?White powder,?Water?0.36%,?Single Impurity?0.37%.Netarsudil HClNetarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and?/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1?nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16?nM, respectively, and blocked the profibrotic effects of TGF-??2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24?h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.Product Details:Name: Netarsudil HClCAS#: 1253952-02-1 (HCl)Chemical Formula: C28H29Cl2N3O3Exact Mass: 525.1586Molecular Weight: 526.45Elemental Analysis: C, 63.88; H, 5.55; Cl, 13.47; N, 7.98; O, 9.12Specification:Synonym: Netarsudil; Netarsudil hydrochloride; AR-13324 HCl; AR-13324 HCl; AR13324 HCl; AR13324 HCl; Rhopressa;IUPAC/Chemical Name: [4-[(2S)-3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate dihydrochlorideInChi Key: LDKTYVXXYUJVJM-FBHGDYMESA-NInChi Code: InChI=1S/C28H27N3O3.2ClH/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;;/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H/t26-;;/m1../s1SMILES Code: O=C(OCC1=CC=C([C@@H](CN)C(NC2=CC3=C(C=NC=C3)C=C2)=O)C=C1)C4=CC=C(C)C=C4C.[H]Cl.[H]ClAppearance: White powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certifications: