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CAS Number：1393477-72-9
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SMILES：Selinexor, CAS 1393477-72-9Sln? Selinexor, CAS 1393477-72-9,?Stock?791g,?Assay?98.74%,?White powder,?Water?0.27%,?Single Impurity?0.32%.KPT-330Selinexor, also known as KPT-330, is an orally bioavailable, potent and selective XPO1/CRM1 Inhibitor. Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia. Selinexor potentiates the antitumor activity of gemcitabine in human pancreatic cancer through inhibition of tumor growth, depletion of the antiapoptotic proteins, and induction of apoptosis. Selinexor has strong activity against primary AML cells while sparing normal stem and progenitor cells.Product Details:Name: Selinexor free baseCAS#: 1393477-72-9 (free base)Chemical Formula: C17H11F6N7OExact Mass: 443.09293Molecular Weight: 443.31Elemental Analysis: C, 46.06; H, 2.50; F, 25.71; N, 22.12; O, 3.61Specification:Related CAS #: 1393477-72-9 (free base)? ?1421923-86-5 (E-isomer)? ?1621865-82-4 (E-isomer)? ?Unknown (HCl)? ??Synonym: KPT-330; KPT330; KPT 330; Selinexor; XpovioIUPAC/Chemical Name: (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazideInChi Key: DEVSOMFAQLZNKR-RJRFIUFISA-NInChi Code: InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-SMILES Code: O=C(NNC1=NC=CN=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2Appearance: White powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: