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CAS Number：1420477-60-6
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SMILES：Acalabrutinib (Acp-196), CAS1420477-60-6Acalabrutinib (Acp-196), CAS1420477-60-6,?Stock?749g,?Assay?98.52%,?White powder,?Water?0.34%,?Single Impurity?0.32%.ACP-196Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton??s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.Product Details:Name: Acalabrutinib (ACP-196)CAS#: 1420477-60-6 (free base)Chemical Formula: C26H23N7O2Exact Mass: 465.19132Molecular Weight: 465.52Elemental Analysis: C, 67.08; H, 4.98; N, 21.06; O, 6.87Specification:Related CAS #: 1420477-60-6 (free base)? ?2242394-65-4 (maleate)? ?2058091-93-1 (3 hydrate)? ?2058091-94-2 (fumarate)? ?2058091-96-4 (phosphate)? ?2058091-99-7 (citrate)? ?2058091-97-5 (tartrate)? ?2058092-05-8 (sulfate)??Synonym: ACP-196; ACP196; ACP 196; AcalabrutinibIUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamideInChi Key: WDENQIQQYWYTPO-IBGZPJMESA-NInChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2Appearance: white powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: