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CAS Number：1597403-47-8
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SMILES：trans-ISRIB, CAS?1597403-47-8:trans-ISRIB,?CAS?1597403-47-8,?Stock?245g,?Assay?99.15%,?White powder,?Water?0.23%,?Single Impurity?0.16%.trans-ISRIBtrans-ISRIB is an Integrated Stress Response Inhibitor. trans-ISRIB inhibits the eIF2?? phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). ISRIB reverses the effects of eIF2?? phosphorylation on translation and stress granule assembly. ISRIB reverses the effects of eIF2?? phosphorylation on translation and stress granule assemblyProduct Details:Name: trans-ISRIBCAS#: 1597403-47-8 (trans-isomer)Chemical Formula: C22H24Cl2N2O4Exact Mass: 450.1113Molecular Weight: 451.344Elemental Analysis: C, 58.55; H, 5.36; Cl, 15.71; N, 6.21; O, 14.18Specification:Related CAS #: 1597403-47-8 (trans-isomer)? ?548470-11-7? ??Synonym: trans-ISRIBIUPAC/Chemical Name: N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)InChi Key: HJGMCDHQPXTGAV-IYARVYRRSA-NInChi Code: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17-,18-SMILES Code: O=C(N[C@H]1CC[C@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3Appearance: Solid powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: