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CAS Number：159857-80-4
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SMILES：Mc-Val-Cit-PAB, CAS?159857-80-4:Mc-Val-Cit-PAB,?CAS?159857-80-4,?Stock?176g,?Assay?99.11%,?White powder,?Water?0.23%,?Single Impurity?0.17%.Mc-Val-Cit-PABMc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells.Product Details:Name: Mc-Val-Cit-PABCAS#: 159857-80-4 (MC-Val-Cit-PAB)Chemical Formula: C28H40N6O7Exact Mass: 572.2958Molecular Weight: 572.663Elemental Analysis: C, 58.73; H, 7.04; N, 14.68; O, 19.56Specification:Related CAS #: 159857-80-4 (MC-Val-Cit-PAB)? ?159857-81-5 (MC-Val-Cit-PAB-PNP)? ?159857-79-1 (Val-cit-PAB-OH)? ??Synonym: Mc-Val-Cit-PABIUPAC/Chemical Name: N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamideInChi Key: UMDCMQHPXQLHGR-OFVILXPXSA-NInChi Code: InChI=1S/C28H40N6O7/c1-18(2)25(32-22(36)8-4-3-5-16-33-23(37)13-14-24(33)38)27(40)34(20-11-9-19(17-35)10-12-20)21(26(29)39)7-6-15-31-28(30)41/h9-14,18,21,25,35H,3-8,15-17H2,1-2H3,(H2,29,39)(H,32,36)(H3,30,31,41)/t21-,25-/m0/s1SMILES Code: O=C(N)[C@H](CCCNC(N)=O)N(C([C@H](C(C)C)NC(CCCCCN1C(C=CC1=O)=O)=O)=O)C2=CC=C(CO)C=C2Appearance: Solid powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >3 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: