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CAS Number：159857-81-5
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SMILES：MC-Val-Cit-PAB-PNP, CAS?159857-80-4:MC-Val-Cit-PAB-PNP,?CAS?159857-81-5,?Stock?236g,?Assay?99.12%,?White powder,?Water?0.25%,?Single Impurity?0.17%.MC-Val-Cit-PAB-PNPMC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. The Val-Cit will specifically be cleaved by catepsin B. Because this enzyme is only present in the lysosome, the ADC payload will only be released in the cell. The Azido group will react with DBCO, BCN or other Alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. * * * * * * Please also see similar products: #610235: MC-Val-Cit-PAB (ADC peptide linker) and #610234: MC-Val-Cit-PAB-PNP (ADC peptide linker); #620108 Val-cit-PAB-OH (ADC peptide linker).Product Details:Name: MC-Val-Cit-PAB-PNPCAS#: 159857-81-5 (MC-Val-Cit-PAB-PNP)Chemical Formula: C35H43N7O11Exact Mass: 737.3021Molecular Weight: 737.767Elemental Analysis: C, 56.98; H, 5.88; N, 13.29; O, 23.85Specification:Related CAS #: 159857-80-4 (MC-Val-Cit-PAB)? ?159857-81-5 (MC-Val-Cit-PAB-PNP)? ?159857-79-1 (Val-cit-PAB-OH)? ??Synonym: MC-Val-Cit-PAB-PNP; Mc-Val-Cit-PABC-PNP; Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate. Mc-Val-Cit-PABIUPAC/Chemical Name: 4-((S)-N-((S)-1-amino-1-oxo-5-ureidopentan-2-yl)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)benzyl (4-nitrophenyl) carbonateInChi Key: UQRQGHMQKAXOTE-DHIFEGFHSA-NInChi Code: InChI=1S/C35H43N7O11/c1-22(2)31(39-28(43)8-4-3-5-20-40-29(44)17-18-30(40)45)33(47)41(27(32(36)46)7-6-19-38-34(37)48)24-11-9-23(10-12-24)21-52-35(49)53-26-15-13-25(14-16-26)42(50)51/h9-18,22,27,31H,3-8,19-21H2,1-2H3,(H2,36,46)(H,39,43)(H3,37,38,48)/t27-,31-/m0/s1SMILES Code: O=C([C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O)NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=OAppearance: Solid powderPurity: >95% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: